Lipids & metabolic liver disease
Association of Phenotypic Age Acceleration With Pancreatic Fat Percentage in a UK Biobank Imaging Population
Authors' conclusion
Phenotypic age acceleration was associated with higher mean pancreatic fat percentage in a large UK Biobank imaging population.
Study context
- Population
- UK Biobank participants who attended the initial assessment and the first imaging visit
- Participants
- 23,558 participants
- Exposure
- Phenotypic age acceleration
- Outcome
- Pancreatic fat as proton density fat fraction (PDFF) from abdominal MRI
Methodological detailsUK Biobank imaging population, multivariable-adjusted generalised linear models (gamma distribution, log link), subgroup and sensitivity analyses
- UK Biobank imaging population
- Multivariable-adjusted generalised linear models (gamma distribution, log link)
- Subgroup and sensitivity analyses
Main finding
As reported in the abstract
Mean pancreatic PDFF
Mean ratio
1.02
95% CI 1.02–1.03
Per 1-year increase in phenotypic age acceleration · 2% higher; multivariable-adjusted
Mean ratio
1.37
95% CI 1.33–1.40
Highest quartile vs Lowest quartile · 37% higher
Observational data: associations, not effects.
Further findings
Biologically older (positive phenotypic age acceleration)
- People identified as biologically older
- 8559 (36.3%)
Subgroup and sensitivity analyses
- Subgroup analyses showed broadly consistent associations
- Interactions observed for sex and non-fasting TG, but results were comparable
- Sensitivity analyses showed consistent results
Original publication
Association of Phenotypic Age Acceleration With Pancreatic Fat Percentage in a UK Biobank Imaging Population. Diabetes Obes Metab. Published 21 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →