Lipids & metabolic liver disease
Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis
Authors' conclusion
An elevated TyG index is associated with an increased risk of arterial stiffness and CAC. Prospective studies are needed to assess causality.
Study context
- Population
- Observational studies of the triglyceride and glucose (TyG) index and arterial stiffness or coronary artery calcification (CAC); PubMed, Cochrane Library and Embase until September 2022
- Participants
- 87,307 participants26 observational studies
- Comparison
- Higher vs lower TyG index
- Outcome
- Arterial stiffness and CAC
Methodological detailsrandom-effects model, robust error meta-regression (exposure-effect)
- Random-effects model
- Robust error meta-regression (exposure-effect)
Pooled result
As reported in the abstract
- Arterial stiffness, category analysis: OR
- 1.83 (95% CI 1.55-2.17, I2 = 68%)
- CAC, category analysis: OR
- 1.66 (95% CI 1.51-1.82, I2 = 0)
- Arterial stiffness, per 1-unit TyG increment: OR
- 1.51 (95% CI 1.35-1.69, I2 = 82%)
- CAC, per 1-unit TyG increment: OR
- 1.73 (95% CI 1.36-2.20, I2 = 51%)
- Positive nonlinear association of TyG index with arterial stiffness risk
- Pnonlinearity < 0.001
Further pooled results
Progression of CAC
- Category analysis: OR
- 1.66 (95% CI 1.21-2.27, I2 = 0)
- Continuity analysis: OR
- 1.47 (95% CI 1.29-1.68, I2 = 41%)
Original publication
Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis. Cardiovasc Diabetol. Published 13 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →