Lipids & metabolic liver disease
Association between the triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome
Main finding · MACE in CMD patientsResult — go to the resultHazard ratio 2.132 95% CI 1.066–4.261Authors' conclusion
TyG index is significantly associated with the risk of CMD, and it is an independent predictor of MACE among CMD patients with CCS. This study suggests that the TyG index has important clinical significance for the early prevention and risk stratification of CMD.
Study context
- Population
- Patients with chronic coronary syndrome who underwent coronary angiography, June 2015 to June 2019; Coronary microvascular dysfunction (CMD) defined as caIMR ≥ 25U221 with CMD
- Participants
- 430 patients
- Exposure
- TyG index tertiles among CMD patients
- Outcome
- MACE
Main finding
MACE in CMD patients · follow-up
Hazard ratio
2.132
95% CI 1.066–4.261
P = 0.032
By group
T3
39.2%
T3vs T1
HR 2.132 (95% CI 1.066–4.261); P = 0.032
As reported in the abstract
- Major adverse cardiac event (MACE) events recorded among CMD patients
- 63
Observational data: associations, not effects.
Further findings
Presence of CMD
- TyG index independent predictor of CMD, multivariable logistic regression: OR
- 1.436 (95% CI 1.014-2.034; P = 0.042)
- CMD patients had significantly higher TyG index than those without CMD
Original publication
Association between the triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome. Cardiovasc Diabetol. Published 13 May 2023. doi:10.
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