Lipids & metabolic liver disease
Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue
Authors' conclusion
Simvastatin treatment was linked to mitochondrial respiratory capacity in human subcutaneous white adipose tissue, but no clear link was found between statin exposure, respiratory changes, and inflammatory status of adipose tissue.
Study context
- Population
- Adults with elevated plasma cholesterol; subcutaneous white adipose tissue
- Participants
- 55 adults
- Exposure
- Simvastatin-treated patients vs controls
- Simvastatinn = 38
- Controlsn = 17reference
- Outcome
- Mitochondrial respiratory capacity in white adipose tissue (high-resolution respirometry)
Methodological detailsmatched on age, BMI and maximal oxygen consumption
- Matched on age, BMI and maximal oxygen consumption
Main finding
As reported in the abstract
- Simvastatin vs Controls: P = 0.0001 when normalized to wet weight
- Simvastatin vs Controls: P < 0.0001 when normalized to citrate synthase activity [intrinsic]
- Simvastatin vs Controls: P = 0.0004
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Plasma lipidsSimvastatin vs Controls · lower plasma cholesterol with Simvastatin | P < 0.0001 |
| Plasma lipidsSimvastatin vs Controls · lower LDL with Simvastatin | P < 0.0001 |
| Plasma lipidsSimvastatin vs Controls · lower TG with Simvastatin | P = 0.0116 |
| IL-6 expression in subcutaneous white adipose tissueHigher IL-6 expression with Simvastatin | P = 0.0202 |
Original publication
Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue. J Clin Endocrinol Metab. Published 10 May 2023. doi:10.
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