Lipids & metabolic liver disease
The synergistic effect of the triglyceride-glucose index and serum uric acid on the prediction of major adverse cardiovascular events after coronary artery bypass grafting: a multicenter retrospective cohort study
Authors' conclusion
The TyG index interacts synergistically with SUA to increase the risk of MACE in patients undergoing CABG, which emphasizes the need to use both measures concurrently when assessing cardiovascular risk.
Study context
- Population
- Patients who underwent coronary artery bypass grafting (CABG), grouped by triglyceride-glucose (TyG) index cut-off and sex-specific hyperuricemia criteria
- Participants
- 1,225 patients
- Exposure
- Higher TyG index and hyperuricemia vs other TyG/serum uric acid (SUA) categories
- Outcome
- MACE
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
follow-up
- Patients developing major adverse cardiovascular events (MACE) during follow-up
- 263
- Higher TyG index and hyperuricemia: higher risk of MACE (Kaplan-Meier log-rank)
- P < 0.001
- Higher TyG index and hyperuricemia, Cox regression HR
- 4.10 (2.80-6.00), P < 0.001 (95% CI)
Observational data: associations, not effects.
Further findings
Interaction between TyG index and SUA
- RERI
- 1.83 (0.32-3.34), P = 0.017 (95% CI)
- Attributable proportion (AP)
- 0.41 (0.17-0.66), P = 0.001 (95% CI)
- Synergy index (SI)
- 2.13 (1.13-4.00), P = 0.019 (95% CI)
- Significant synergistic interaction
Prediction and model fit with addition of TyG index and SUA
- Change in C-statistic
- 0.038, P < 0.001
- Continuous net reclassification improvement (NRI)
- 0.336 (0.201-0.471), P < 0.001 (95% CI)
- Integrated discrimination improvement (IDI)
- 0.031 (0.019-0.044), P < 0.001 (95% CI)
- Akaike information criterion (AIC)
- 3534.29
- Bayesian information criterion (BIC)
- 3616.45
- Likelihood ratio test
- P < 0.001
Original publication
The synergistic effect of the triglyceride-glucose index and serum uric acid on the prediction of major adverse cardiovascular events after coronary artery bypass grafting: a multicenter retrospective cohort study. Cardiovasc Diabetol. Published 2 May 2023. doi:10.
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