Lipids & metabolic liver disease
Triglyceride-glucose index, symptomatic intracranial artery stenosis and recurrence risk in minor stroke patients with hypertension
Main finding · Stroke recurrenceResult — go to the resultHazard ratio 2.02 95% CI 1.07–3.84Authors' conclusion
TyG is a significant risk factor for sICAS in hypertensive patients, and there is a synergistic effect of sICAS and higher TyG on ischemic stroke recurrence.
Study context
- Population
- Patients with acute minor ischaemic stroke and preadmission diagnosis of hypertension, September 2019 to November 2021; mean age 61.6 ± 11.6 years, 70.1% male, 26.4% with symptomatic intracranial atherosclerosis (sICAS)
- Participants
- 1,281 patients
- Exposure
- Triglyceride-glucose (TyG) quartiles; high vs low TyG combined with sICAS
- Outcome
- Ischaemic stroke recurrence
- Follow-up
- 90-day follow-up
Methodological detailsmulticentre
- Multicentre
Main finding
Stroke recurrence · 90 days
Hazard ratio
2.02
95% CI 1.07–3.84
P = 0.025
Q4 TyGvs Q1 TyG
HR 2.02 (95% CI 1.07–3.84); P = 0.025
As reported in the abstract
- Patients with stroke recurrence during follow-up
- 117
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| sICASQ4 TyGvs Q1 TyGAdjusted for confounders | OR 1.59 (95% CI 1.04–2.43) | P = 0.033 | |
| Stroke recurrence by TyG (threshold 8.4) and sICASHigh TyG with sICASvs Low TyG without sICAS | HR 2.54 (95% CI 1.39–4.65) | ||
| 0.20.5125Ratio (log scale) |
| Outcome | P value |
|---|---|
| Stroke recurrence by TyG (threshold 8.4) and sICASTyG × sICAS · interaction effect on stroke recurrence | P = 0.043 |
- sICAS — Linear relationship between TyG and sICAS on restricted cubic spline (RCS); TyG threshold
- 8.4
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Triglyceride-glucose index, symptomatic intracranial artery stenosis and recurrence risk in minor stroke patients with hypertension. Cardiovasc Diabetol. Published 19 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →