Lipids & metabolic liver disease
Joint association of triglyceride-glucose (TyG) and atherogenic index of plasma (AIP) with stroke risk: findings from a nationwide prospective cohort
Authors' conclusion
Both the TyG index and AIP are independent risk factors for stroke. The primary value of combining these two indicators lies in identifying individuals at extremely high risk, rather than significantly enhancing overall predictive performance.
Study context
- Population
- Adults aged ≥ 45 years without baseline stroke, China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 7,652 adults
- Exposure
- High vs low TyG index and AIP, alone and combined
- Outcome
- New-onset stroke
- Follow-up
- Over 9 years
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Hazard ratio (95% CI)
High TyGindependently increased risk
1.41(1.21–1.64)
High AIPindependently increased risk
1.44(1.24–1.67)
Combinationhighest risk
1.49(1.27–1.75)
- Strokes
- 744 (9.72%)
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic spline (RCS))
- AIP nonlinear association, inflection
- ≈0.22
- TyG linear association
Predictive performance of combined indices
- Combined AUC, not significantly better (DeLong test)
- 0.633
- DeLong test
- P > 0.05
- Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) non-significant
Interaction TyG × AIP
- Multiplicative interaction significant
- P = 0.021
- Additive interaction non-significant, RERI
- 0.280 (95% CI −0.220-0.779)
Subgroups
- Stronger effects of combined indicators in age < 60 years and those without diabetes or heart disease history
Original publication
Joint association of triglyceride-glucose (TyG) and atherogenic index of plasma (AIP) with stroke risk: findings from a nationwide prospective cohort. Cardiovasc Diabetol. Published 3 April 2026. doi:10.
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