Lipids & metabolic liver disease
Combined association of triglyceride-glucose index and the atherogenic index of plasma with the incidence of cardiovascular diseases among middle-aged and older population
Authors' conclusion
Both baseline and longitudinal changes of TyG-AIP were independently associated with the risk of developing CVDs, especially stroke, in middle-aged and older Chinese adults. Repeated assessment of TyG-AIP captured cardiometabolic deterioration over time and improved identification of individuals at elevated cardiovascular risk. Incorporating long-term monitoring of TyG-AIP into routine health evaluations may enhance population-level CVDs risk prediction and support more effective prevention strategies.
Study context
- Population
- Middle-aged and older adults, China Health and Retirement Longitudinal Study (CHARLS), 2012–20204,134 in longitudinal analysis
- Participants
- 6,986 participants
- Exposure
- Tertiles of TyG-AIP index
- Outcome
- Incident CVD (stroke and heart disease)
- Follow-up
- Median 8.0 years
Methodological detailspopulation-based, longitudinal trajectory analysis, K-means clustering
- Population-based
- Longitudinal trajectory analysis
- K-means clustering
Main finding
As reported in the abstract
- Incident CVD events
- 1,752
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| StrokeT2vs T1 | 1.40 (1.14–1.74) | |
| StrokeT3vs T1 | 1.52 (1.23–1.88) | |
| 0.512Adjusted hazard ratio (log scale) |
- Stroke — Incident stroke cases
- 614
- Stroke — Incident heart disease cases
- 1,343
Discrimination of TyG-AIP (modest but superior to triglyceride-glucose (TyG) or atherogenic index of plasma (AIP) alone)
- AUC for CVD
- 0.611
- AUC for stroke
- 0.631
- AUC for heart disease
- 0.605
Risk reclassification adding TyG-AIP
- NRI for CVD (P < 0.001)
- 0.036-0.054
- NRI for stroke (P < 0.001)
- 0.096-0.114
Persistently high and rising TyG-AIP trajectory cluster (longitudinal analysis)
- CVD, adjusted HR
- 1.25 (95% CI 1.04-1.51)
- Stroke, HR
- 1.43 (95% CI 1.05-1.95)
- Heart disease, HR
- 1.25 (95% CI 1.01-1.54)
- N = 4,134
Original publication
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