Lipids & metabolic liver disease
Evaluation of a Fixed‐Dose Insulin Protocol for Hypertriglyceridemia‐Induced Acute Pancreatitis: A Retrospective Cohort Study
Authors' conclusion
The fixed-dose insulin protocol demonstrated similar clinical outcomes to historical care with an acceptable safety profile. This protocol offers a reproducible and standardized approach to managing HTG-AP in diverse inpatient settings.
Study context
- Population
- Adults admitted with hypertriglyceridemia-induced acute pancreatitis (HTG-AP), 15 July 2017 to 10 October 2024, across a healthcare system
- Participants
- 466 adults
- Exposure
- Fixed-dose insulin drip protocol vs historical care
- Post-protocoln = 224
- Pre-protocoln = 242reference
- Outcome
- ICU LOS
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
- No statistically significant difference in intensive care unit (ICU) LOS between groups
Observational data: associations, not effects.
Secondary outcomes
Hospital LOS and time to triglyceride <1000 mg/dL (11.3 mmol/L)
- No statistically significant differences in hospital LOS or time to triglyceride reduction
Safety
Mild hypoglycemia · more common post-protocol
P = 0.008
Severe hypoglycemia and hypokalemia
- Rates low and comparable between groups
Original publication
Evaluation of a Fixed‐Dose Insulin Protocol for Hypertriglyceridemia‐Induced Acute Pancreatitis: A Retrospective Cohort Study. Clin Endocrinol (Oxf). Published 4 December 2025. doi:10.
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