Lipids & metabolic liver disease
Apolipoprotein CIII correlates with lipoproteins in the fed state and is not regulated by leptin administration in states of hypoleptinemia induced by acute or chronic energy deficiency: Results from two randomised controlled trials
Authors' conclusion
These results contribute towards our better understanding of the intricate nature of lipid regulation under energy deficiency, suggesting that medications targeting the leptin and APOC3 pathways act through different metabolic pathways and thus may have independent effects from each other in regulating triglycerides.
Study context
- Population
- Study-1: healthy individuals; Study-2: females with hypoleptinemia due to relative energy deficiency in sport (REDs) for ≥6 monthsStudy-1 n=15
- Comparison
- Leptin vs placebo under acute or chronic energy deficiency
- Primary endpoint
- APOC3 levels and their association with circulating lipids and lipoproteins
Methodological detailsplacebo-controlled, Study-1: crossover-type conditions each lasting 72 h
- Placebo-controlled
- Study-1: crossover-type conditions each lasting 72 h
Primary result
As reported in the abstract
APOC3 levels
- Study-1: Apolipoprotein CIII (APOC3) levels remained stable across all arms and were unaffected by leptin
- Study-1, fed state: APOC3 positively correlated with various VLDL, IDL, LDL and HDL sizes and free fatty acids (FFA), mostly not replicated in fasting
- Study-1, fasting: APOC3 correlated with HDL molecules, glutamine and FFA; under leptin, positively associated only with FFA
- Study-2: APOC3 lower in leptin group, but not a leptin-dependent effect
- Study-2: positive correlation between APOC3 and HDL in leptin group
Original publication
Apolipoprotein CIII correlates with lipoproteins in the fed state and is not regulated by leptin administration in states of hypoleptinemia induced by acute or chronic energy deficiency: Results from two randomised controlled trials. Diabetes Obes Metab. Published 15 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →