Lipids & metabolic liver disease
Estimated Glucose Disposal Rate Predicts the Risk of Incident Metabolic Dysfunction-Associated Steatotic Liver Disease
Authors' conclusion
Lower eGDR levels were associated with an increased risk of incident MASLD. Our findings suggest that eGDR may be a more effective tool for predicting MASLD risk.
Study context
- Population
- Participants of a health check-up program3,654 developed MASLD
- Participants
- 16,689 participants
- Exposure
- Estimated glucose disposal rate (eGDR) quartiles
- Outcome
- Incident MASLD
Methodological detailshealth check-up program
- Health check-up program
Main finding
As reported in the abstract
Odds ratio (95% CI)
Q2vs Q1 (lowest eGDR)
0.775(0.692–0.868)
Q3vs Q1 (lowest eGDR)
0.478(0.408–0.560)
Q4 (highest eGDR)vs Q1 (lowest eGDR)
0.147(0.110–0194)
Observational data: associations, not effects.
Further findings
| Outcome | eGDR | TG/HDL ratio | Triglyceride glucose index |
|---|---|---|---|
| Prediction of incident MASLD (AUC) | |||
| AUC | 0.8 (95% CI 0.79-0.81) | 0.76 (95% CI 0.79-0.81) | 0.75 (95% CI 0.74-0.76) |
Association by sex and obesity status
- Association between lower eGDR and MASLD risk consistent across stratification by sex and obesity status
Prediction of incident MASLD (AUC)
- AUC for eGDR higher than for TG/HDL ratio and triglyceride glucose index
Original publication
Estimated Glucose Disposal Rate Predicts the Risk of Incident Metabolic Dysfunction-Associated Steatotic Liver Disease. Endocr Pract. Published 15 January 2025. doi:10.
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