Lipids & metabolic liver disease
Insulin resistance assessed by estimated glucose disposal rate and risk of incident cardiovascular diseases among individuals without diabetes: findings from a nationwide, population based, prospective cohort study
Authors' conclusion
A lower level of eGDR was found to be associated with increased risk of incident CVD among non-diabetic participants. This suggests that eGDR may serve as a promising and preferable predictor and intervention target for CVD.
Study context
- Population
- Individuals without cardiovascular diseases (CVD) or DM with complete baseline estimated glucose disposal rate (eGDR) data, China Health and Retirement Longitudinal Study (CHARLS); mean age 58.2 ± 8.8 years, 54.1% female
- Participants
- 5,512 individuals
- Exposure
- eGDR quartiles Q2–Q4 vs Q1
- Outcome
- Incident CVD
- Follow-up
- Median 79.4 months
Methodological detailsnationwide, population based
- Nationwide
- Population based
Main finding
As reported in the abstract
Incident CVD (multivariate adjusted)
Each group vs Q1Hazard ratio (95% CI)
Q2
0.88(0.76–1.02)
Q3
0.69(0.58–0.82)
Q4
0.66(0.56–0.79)
- Incident CVD cases
- 1213
- Per 1.0-SD increase in eGDR: 17% lower CVD risk, HR
- 0.83 (95% CI 0.78 - 0.89)
Observational data: associations, not effects.
Further findings
Incident heart disease and stroke cases
- Heart disease cases
- 927
- Stroke cases
- 391
Dose-response (restricted cubic spine (RCS))
- Significant and linear relationship between eGDR and all outcomes
- all P for non-linearity > 0.05
Effect modification by smoking status
- Smoking status modified the association
- P for interaction = 0.012
Mediation and prediction
- Obesity partly mediated the association
- Adding eGDR to the basic model considerably improved CVD prediction
Original publication
Insulin resistance assessed by estimated glucose disposal rate and risk of incident cardiovascular diseases among individuals without diabetes: findings from a nationwide, population based, prospective cohort study. Cardiovasc Diabetol. Published 6 June 2024. doi:10.
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