Lipids & metabolic liver disease
The association between liver fat content and plasma metabolite profiles in fasting and postprandial states: an integration of a cohort study and a randomized controlled trial
Authors' conclusion
Postprandial metabolomic profiling revealed additional associations between liver fat content and plasma metabolites beyond fasting measures, particularly in lipoprotein cholesterol and fatty acid composition. Diet-induced reductions in liver fat were associated with favorable changes in fasting metabolites, but not postprandial metabolite responses. Future studies with harmonized postprandial assessment are needed to further elucidate the postprandial observations and the underlying mechanisms.
Study context
- Population
- Subpopulation of an existing cohort study and participants of a 12-week dietary intervention studycohort n = 1986
- Comparison
- High vs low liver fat content
- Primary endpoint
- Associations between liver fat content and plasma metabolites at fasting (T0), 150 min after a mixed meal (T150) and postprandial response (ΔT150-T0)
Methodological detailsintegrated analysis, 12-week dietary intervention, liver fat by proton magnetic resonance spectroscopy, NMR metabolomics at fasting and after a mixed meal
- Integrated analysis
- 12-week dietary intervention
- Liver fat by proton magnetic resonance spectroscopy
- NMR metabolomics at fasting and after a mixed meal
Primary result
As reported in the abstract
- High liver fat: higher fasting and postprandial TG, all VLDL and small LDL/HDL subclasses, ApoB, fatty acids, glycoprotein acetyls and BCAAs; lower medium/larger HDL subclasses and acetate vs low liver fat
- High vs low liver fat: lower postprandial responses of cholesterol content of S-LDL, IDL and S-HDL, glutamine, histidine, omega-3% and DHA %
Further findings
Diet-induced change in liver fat and fasting plasma metabolites (intervention study) · 12 weeks
- Diet-induced reductions in liver fat associated with reductions in fasting plasma metabolites, incl. VLDL-TG, tyrosine, isoleucine, fatty acid ratios and most VLDL subclasses
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Original publication
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