Lipids & metabolic liver disease
Association of cumulative exposure to cholesterol, high‐density lipoprotein, and glucose index with the risk of cardiovascular disease and all‐cause mortality: A longitudinal cohort study
Authors' conclusion
The high cumulative CHG was associated with an increased risk of CVD and all-cause mortality, demonstrating superior predictive performance compared to both baseline CHG and other cumulative metabolic indices. The study highlights the significance of the long-term monitoring of the CHG index in clinical practice.
Study context
- Population
- Participants of the Kailuan cohort; cumulative CHG from 2006–2010 surveys
- Participants
- 53,700 participants
- Exposure
- Highest vs lowest quartile of cumulative CHG; 6 years vs no exposure to high CHG
- Outcome
- Incident CVD and all-cause mortality
- Follow-up
- 2010 to 2021; median 11.06 years
Methodological detailslongitudinal, multivariate Cox proportional hazards regression
- Longitudinal
- Multivariate Cox proportional hazards regression
Main finding
As reported in the abstract
median follow-up 11.06 years
Estimate (95% CI)
Q4vs Q1
HR (incident CVD) 1.70(1.55–1.88)
Q4vs Q1
HR (all-cause mortality) 1.22(1.13–1.33)
- Cardiovascular disease (CVD) events
- 3739
- All-cause mortality events
- 4853
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Exposure duration of high CHG: 6 years vs no exposure6-year exposurevs No exposure | HR (incident CVD) 1.79 (95% CI 1.61–1.98) | |
| Exposure duration of high CHG: 6 years vs no exposure6-year exposurevs No exposure | HR (all-cause mortality) 1.23 (95% CI 1.13–1.34) | |
| 0.512Ratio (log scale) |
Predictive value (ROC analysis)
- Cumulative CHG had superior predictive value for CVD and all-cause mortality vs baseline CHG, outperforming other insulin resistance (IR) indices
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of cumulative exposure to cholesterol, high‐density lipoprotein, and glucose index with the risk of cardiovascular disease and all‐cause mortality: A longitudinal cohort study. Diabetes Obes Metab. Published 1 December 2025. doi:10.
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