Lipids & metabolic liver disease
Triglyceride Clearance in Hypertriglyceridemic Pancreatitis: Time Course and Its Implications for Management
Authors' conclusion
A threshold of 4000 mg/dL for the initial Tg levels in HTg pancreatitis appears to separate patients who are likely to achieve Tg levels of <1000 mg/dL in <3 versus >3 days, independent of cause or treatment. Insulin therapy is appropriate for patients with hyperglycemia but appears unnecessary for those with isolated ethanol-associated HTg. A threshold Tg level of <1000 mg/dL appears more practical than that of <500 mg/dL for resuming nutritional intake.
Study context
- Population
- Patients hospitalized October 2013–December 2018 with pancreatitis associated with hypertriglyceridemic (HTg) (triglyceride (Tg) ≥500 mg/dL), in the absence of other causes45 with time-course data
- Participants
- 66 patients
- Outcome
- Time course of Tg lowering by initial Tg values, causes and interventions
Methodological detailsmedical record review
- Medical record review
Main finding
As reported in the abstract
Higher initial Tg: took 5-9 days
18.8%
Observational data: associations, not effects.
Further findings
Duration of HTg by insulin and ethanol
- Insulin therapy associated with longer duration of HTg; ethanol with shorter duration
- Tg clearance in ethanol-associated HTg appeared independent of insulin treatment
Time to Tg <500 vs <1000 mg/dL
- Significantly longer when initial Tg >2000 mg/dL
Original publication
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