Lipids & metabolic liver disease
Steatotic liver disease interacts with a polygenic risk score for triglyceride clearance to impact the risk of hypertriglyceridaemia: The Maastricht Study
Authors' conclusion
Genetically predisposed individuals have a substantially higher risk of hypertriglyceridaemia when they also have steatotic liver disease. This gene-environment interaction might contribute to more personalised treatment approaches, which require further exploration in future studies.
Study context
- Population
- The Maastricht Study participants; age 60 years, 48% women, 10% hypertriglyceridaemia, 26% steatotic liver disease
- Participants
- 3,810 participants
- Exposure
- Interaction between intrahepatic lipid (IHL) content and a polygenic risk score (PRS) for TG clearance
- Outcome
- Fasting serum TG (interaction of IHL content and PRS for TG clearance)
Methodological detailsThe Maastricht Study, multivariable linear regression, adjusted for sociodemographic, lifestyle and CV risk factors
- The Maastricht Study
- Multivariable linear regression
- Adjusted for sociodemographic, lifestyle and CV risk factors
Main finding
As reported in the abstract
| Group | OR high PRS for hypertriglyceridaemia |
|---|---|
| Steatotic liver disease | 6.196 (95% CI 3.966, 9.768) |
| No steatotic liver disease | 1.618 (95% CI 1.110, 2.380) |
OR high PRS for hypertriglyceridaemia
Steatotic liver disease6.196 (95% CI 3.966, 9.768)
No steatotic liver disease1.618 (95% CI 1.110, 2.380)
- Interaction between IHL content and PRS on serum TG
- P = 0.005
Observational data: associations, not effects.
Further findings
Incident CVD (longitudinal interaction) · 10 year follow-up
- Similar trend for incident CVD risk
- P = 0.078
Original publication
Steatotic liver disease interacts with a polygenic risk score for triglyceride clearance to impact the risk of hypertriglyceridaemia: The Maastricht Study. Diabetologia. Published 27 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →