Lipids & metabolic liver disease
Effects of obstructive sleep apnea on non-alcoholic fatty liver disease in patients with obesity: a systematic review
Authors' conclusion
For the first time, BMS has been tested in treating both OSA and NAFLD pre and postoperative with positive results. Further research, ideally with histological and functional data, is needed to confirm these findings. The SR identified 14 distinct liver outcome tests; however, high heterogeneity and incomplete data precluded a meta-analysis. It is imperative to pay greater attention to the influence of OSA-related factors and uniformity in liver outcomes testing concerning NAFLD. To accomplish this, study designs should be enhanced by incorporating more comprehensive pre- and postoperative evaluations, extending follow-up periods, and employing a more consistent methodology for liver diagnosis in patients with obesity.
Study context
- Population
- Patients with obesity, obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD); CENTRAL, PubMed and EMBASE28 studies
- Comparison
- Mild-to-moderate OSA vs Severe OSA
- Outcome
- OSA-related indicators predicting presence of NAFLD and effect of MBS on improving OSA and NAFLD over time
Methodological details14 distinct liver outcome tests; high heterogeneity and incomplete data precluded a meta-analysis
- 14 distinct liver outcome tests; high heterogeneity and incomplete data precluded a meta-analysis
Pooled result
As reported in the abstract
- In most studies, significant correlations between OSA, OSA-related outcomes and NAFLD
- Apnea-hypopnea index (AHI) alone an inadequate predictor of NAFLD
- 18 cross-sectional and 10 cohort studies
Further pooled results
- Free from fatty liver after MBS · 6 months after surgery — Mild-to-moderate OSA
- 100%
- Free from fatty liver after MBS — Reduction in severe OSA
- 89%
- Free from fatty liver after MBS: Six studies involved MBS; one evaluated patients before and after MBS
Original publication
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