Lipids & metabolic liver disease
Associations of MAFLD and MAFLD subtypes with the risk of the incident myocardial infarction and stroke
Authors' conclusion
In conclusion, a diagnosis of MAFLD is associated with an increased risk of MI or stroke
Study context
- Population
- Participants in the UK Biobank
- Participants
- 325,129 participants
- Exposure
- MAFLD vs no MAFLD
- Outcome
- Incident MI and stroke
- Follow-up
- Median 12.8 years
Methodological detailsUK Biobank, Cox regression analysis
- UK Biobank
- Cox regression analysis
Main finding
As reported in the abstract
median 12.8 years
MAFLD vs Without MAFLDHazard ratio (95% CI)P value
MI
1.35(1.29–1.41)
P < 0.001Stroke
1.26(1.18–1.33)
P < 0.001Observational data: associations, not effects.
Further findings
MAFLD subtypes and myocardial infarction (MI) and stroke
- Diabetic, overweight with MD, and lean MAFLD subtypes significantly associated with increased risk of MI and stroke; overweight without MD subtype did not appear associated
Liver fibrosis scores and MI and stroke in MAFLD
- Graded associations between liver fibrosis scores and risk of MI and stroke in MAFLD; among subtypes, only diabetic and overweight with MD subtypes showed graded associations
Fatty liver risk alleles
- Risk alleles traits of fatty liver did not enhance the effect of MAFLD on risk of MI and stroke
Original publication
Associations of MAFLD and MAFLD subtypes with the risk of the incident myocardial infarction and stroke. Diabetes Metab. Published 14 August 2023. doi:10.
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