Lipids & metabolic liver disease
The cholesterol, high-density lipoprotein, and glucose (CHG) index as a novel metabolic marker for predicting adverse outcomes in myocardial infarction survivors: insights from two large prospective cohorts
Authors' conclusion
In two large independent cohorts of individuals with prior MI, the CHG index was independently associated with risks of adverse events. While its independent discriminative power is modest, the index serves as a valuable adjunctive tool that enhances risk reclassification, warranting further validation in prospective clinical settings to confirm its utility in secondary prevention.
Study context
- Population
- Individuals with a history of MI: UK Biobank (16,959) and post-MI patients with coronary artery disease from Fuwai Hospital (6,253)two cohorts
- Exposure
- CHG index Q4 vs Q1
- Outcome
- UK Biobank: all-cause and CV mortality; Fuwai Hospital: Major adverse cardiovascular events (MACE) (all-cause mortality, non-fatal MI, ischemia-mediated revascularization) and hard endpoint (CV mortality and non-fatal MI)
- Follow-up
- Median 13.4 years (UK Biobank); 3.1 years (Fuwai)
Methodological detailstwo independent cohorts
- Two independent cohorts
Main finding
As reported in the abstract
All-cause mortality (UK Biobank) · median follow-up 13.4 years
Q4 vs Q1Hazard ratio (95% CI)
Multivariate adjusted; all-cause mortality, UK Biobank
1.39(1.33–1.41)
Multivariate adjusted; CV mortality, UK Biobank
1.42(1.14–1.74)
MACE, Fuwai Hospital, median follow-up 3.1 years
1.37(1.17–1.61)
Hard endpoint, Fuwai Hospital, median follow-up 3.1 years
1.87(1.24–2.81)
Observational data: associations, not effects.
Further findings
Cumulative event rates across CHG quartiles (Kaplan-Meier)
- Significant separation across CHG quartiles in both cohorts
- log-rank P < 0.05
Restricted cubic splines (RCS) dose-response
- Positive linear associations between CHG and all outcomes in both cohorts
Predictive performance (time-dependent ROC)
- CHG index consistently outperformed TyG index model in predicting adverse outcomes
- all FDR-adjusted P < 0.05
Original publication
The cholesterol, high-density lipoprotein, and glucose (CHG) index as a novel metabolic marker for predicting adverse outcomes in myocardial infarction survivors: insights from two large prospective cohorts. Cardiovasc Diabetol. Published 24 February 2026. doi:10.
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