Lipids & metabolic liver disease
Cholesterol, high-density lipoprotein, and glucose index versus triglyceride–glucose index in predicting cardiovascular disease risk: a cohort study
Authors' conclusion
An elevated CHG index is significantly correlated with an increased risk of CVD, demonstrating a linear relationship. Furthermore, it exhibits predictive capabilities comparable to those of the TyG index in assessing CVD risk.
Study context
- Population
- Adults aged 45 and older, CHARLS database, data 2011–2020
- Participants
- 6,249 adults
- Exposure
- CHG index vs Triglyceride-Glucose (TyG) index for predicting cardiovascular disease (CVD) risk
- Outcome
- Incident CVD events
- Follow-up
- nine-year follow-up
Methodological detailsCHARLS database, nine-year follow-up
- CHARLS database
- Nine-year follow-up
Main finding
As reported in the abstract
CVD risk (unadjusted Cox regression), per index
| Group | HR |
|---|---|
| CHG index | 1.35 (95% CI 1.21-1.51, p < 0.001) |
| TyG index | 1.18 (95% CI 1.10-1.27, p < 0.001) |
HR
CHG index1.35 (95% CI 1.21-1.51, p < 0.001)
TyG index1.18 (95% CI 1.10-1.27, p < 0.001)
Observational data: associations, not effects.
Further findings
Incident CVD · nine-year follow-up
- Developed CVD
- 1667 (26.68%)
Restricted cubic spline (RCS) dose-response
- TyG index: non-linear relationship with CVD risk; CHG index: positive linear correlation
Subgroup analysis
- No interaction between subgroups and either index
- P for interaction > 0.05
Original publication
Cholesterol, high-density lipoprotein, and glucose index versus triglyceride–glucose index in predicting cardiovascular disease risk: a cohort study. Cardiovasc Diabetol. Published 10 March 2025. doi:10.
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