Lipids & metabolic liver disease
Impact of healthy lifestyles on the risk of metabolic dysfunction‐associated steatotic liver disease among adults with comorbid hypertension and diabetes: Novel insight from a largely middle‐aged and elderly cohort in South China
Authors' conclusion
In this vulnerable population, daily exercise, abstinence from alcohol and smoking and a low-salt diet may reduce the risk of MASLD, and the most stringent combination of healthy lifestyles could reduce the risk of MASLD by over 90%.
Study context
- Population
- Middle-aged and elderly adults with comorbid hypertension and diabetes, South China, 2010–2023
- Participants
- 41,964 participants
- Exposure
- Healthy lifestyle factors and weighted lifestyle score quartiles vs reference
- Outcome
- Incident MASLD
- Follow-up
- Mean 5.2 years
Methodological detailslongitudinal, marginal structural models
- Longitudinal
- Marginal structural models
Main finding
As reported in the abstract
Each group vs <25th percentileHazard ratio (CI)
25th percentile
0.952(0.902 ≈1.005)
50th percentile
0.747(0.694 ≈0.803)
75th percentile
0.097(0.065 ≈0.144)
- Daily exercise, HR for MASLD
- 0.617 (95% CI 0.365 ≈1.042)
- Never consuming alcohol, HR for MASLD (0.093 ≈0.603)
- 0.237
- Never smoking, HR for MASLD (0.097 ≈0.240)
- 0.153
- Low salt intake, HR for MASLD (0.919 ≈0.971)
- 0.945
- Participants developing MASLD (217 972 person-years)
- 21 697
Observational data: associations, not effects.
Original publication
Impact of healthy lifestyles on the risk of metabolic dysfunction‐associated steatotic liver disease among adults with comorbid hypertension and diabetes: Novel insight from a largely middle‐aged and elderly cohort in South China. Diabetes Obes Metab. Published 7 March 2025. doi:10.
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