The correlation of apolipoprotein B and apolipoprotein A1 with metabolic dysfunction‐associated steatotic liver disease in children and adolescents with obesity
Authors' conclusion
Elevated levels of apoB and the apoB/apoA1 ratio have been strongly connected to increased MASLD prevalence in children and adolescents with obesity; hence, signifying their potential usefulness as biomarkers for early detection and intervention.
Study context
- Population
- Children and adolescents with obesity at a children's hospital, 2020–2022313 with MASLD
- Participants
- 916 children
- Exposure
- Apolipoprotein B (apoB), apolipoprotein A1 (apoA1) and apoB/apoA1 ratio percentiles vs 50th percentile
- Outcome
- Presence of MASLD (US)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
MASLD
Odds (fold higher)
4.83
95% CI 2.02–11.56
apoB 95th percentile
Fold higher prevalence
2.41
95% CI 1.33–4.37
apoB/apoA1 95th percentile
Observational data: associations, not effects.
Original publication
The correlation of apolipoprotein B and apolipoprotein A1 with metabolic dysfunction‐associated steatotic liver disease in children and adolescents with obesity. Pediatr Obes. Published 6 May 2025. doi:10.
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