Examining Biomarkers for Dyslipidemia, Diabetes, and NAFLD by CDC's 2022 Extended BMI Percentiles in US Youth Aged 6–17 Years
Authors' conclusion
Many US youth aged 6-17 with overweight and obesity had borderline or abnormal cardiometabolic biomarkers. Risks varied within obesity: higher extended BMIp were linked to a greater likelihood of borderline or abnormal lab values. Identifying extended BMIp thresholds tied to these risks could facilitate clinical practice, including identifying high-risk patients and informing escalation of care.
Study context
- Population
- US youth aged 6–17 years with BMI ≥ 85th percentile and at least one of total cholesterol, LDL-C, HDL-C, TG, ALT or hemoglobin A1c (HbA1c)
- Exposure
- Higher CDC 2022 extended BMI percentile categories vs overweight
- Outcome
- Borderline or abnormal, and abnormal, cardiometabolic lab values (aPR)
Methodological detailselectronic medical record data
- Electronic medical record data
Main finding
As reported in the abstract
Borderline or abnormal lab values, higher extended BMIp categories vs 85th-< 95th
- HbA1c, adjusted prevalence ratios (aPR) range
- 1.46-2.79
- ALT, aPR range
- 1.58-2.59
- TG, aPR range
- 1.24-1.46
- Total cholesterol, aPR range
- 1.11-1.23
- HDL-C, aPR range
- 1.40-1.94
- LDL-C, aPR range
- 1.23-1.55
Observational data: associations, not effects.
Further findings
- Similar patterns were found for abnormal lab values
Original publication
Examining Biomarkers for Dyslipidemia, Diabetes, and NAFLD by CDC's 2022 Extended BMI Percentiles in US Youth Aged 6–17 Years. Obesity (Silver Spring). Published 21 December 2025. doi:10.
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