Lipids & metabolic liver disease
Additive association of blood group A allele with 15 cardiometabolic diseases: a UK Biobank life-course study
Main finding · VTE risk per additional A allele (additive model)Result — go to the resultHazard ratio 1.273Authors' conclusion
Our findings reveal that blood group A allele is associated with an increased risk of multiple CMD, particularly under the additive model. Some blood cell count traits and blood biochemistries play significant mediating roles.
Study context
- Population
- UK Biobank participants with O and A blood groupsprotein data ≈30,000
- Participants
- over 320,000 participants
- Exposure
- Number of blood group A alleles
- Outcome
- 15 major CMD under recessive, dominant and additive models
Methodological detailsUK Biobank, recessive, dominant and additive genetic models, mediation analysis
- UK Biobank
- Recessive, dominant and additive genetic models
- Mediation analysis
Main finding
As reported in the abstract
VTE risk per additional A allele (additive model)
Hazard ratio
1.273
P[FDR] = 4.43 × 10-96
Observational data: associations, not effects.
Further findings
ABO protein levels and cardiometabolic diseases (CMD)
- ABO protein levels correlated with five CMD outcomes, particularly venous thromboembolism (VTE) and coronary artery disease
- 5
Mediation analysis
- Blood cell traits (e.g., hemoglobin, hematocrit) and biochemistries (e.g., AST/ALT ratio, apolipoprotein B) significantly mediated associations for specific CMD
Original publication
Additive association of blood group A allele with 15 cardiometabolic diseases: a UK Biobank life-course study. Cardiovasc Diabetol. Published 10 March 2025. doi:10.
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