Lipids & metabolic liver disease
Association between estimated glucose disposal rate and cause-specific mortality among individuals with metabolic dysfunction-associated steatotic liver disease
Authors' conclusion
Higher eGDR levels are independently associated with reduced risks of all-cause, cardiovascular, and diabetes mortality among patients with MASLD, highlighting the prognostic relevance of insulin resistance in this population. The modest discriminative performance of eGDR further supports its role in cardiometabolic risk stratification.
Study context
- Population
- Patients with MASLD, National Health and Nutrition Examination Survey (NHANES) 1999–2018
- Participants
- 6,847 patients
- Exposure
- Higher vs lower estimated glucose disposal rate (eGDR)
- Outcome
- All-cause, cardiovascular and diabetes mortality
- Follow-up
- Median 8.8 years
Methodological detailsNHANES 1999-2018
- NHANES 1999-2018
Main finding
As reported in the abstract
All-cause, cardiovascular and diabetes mortality per higher eGDR (adjusted)
- Deaths
- 19.6% (n = 1,345)
- Cardiovascular mortality
- 6.5% (n = 443)
- Diabetes mortality
- 1.3% (n = 89)
- All-cause mortality, HR per higher eGDR
- 0.94 (95% CI 0.92-0.97), P < 0.001
- Cardiovascular mortality, HR per higher eGDR
- 0.90 (95% CI 0.85-0.95), P < 0.001
- Diabetes mortality, HR per higher eGDR
- 0.70 (95% CI 0.62-0.80), P < 0.001
Observational data: associations, not effects.
Further findings
Predictive ability of eGDR (ROC)
- AUC, all-cause mortality
- 0.606
- AUC, cardiovascular mortality
- 0.631
- AUC, diabetes mortality
- 0.729
Subgroup analyses
- Association similar to main results across subgroups
Original publication
Association between estimated glucose disposal rate and cause-specific mortality among individuals with metabolic dysfunction-associated steatotic liver disease. Cardiovasc Diabetol. Published 22 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →