Lipids & metabolic liver disease
Comparison of triglyceride glucose index and modified triglyceride glucose indices in prediction of cardiovascular diseases in middle aged and older Chinese adults
Authors' conclusion
TyG and TyG-WhtR were significantly associated with new-onset cardiovascular diseases, and TyG outperformed the modified TyG indices to identify individuals at risk of incident cardiovascular event.
Study context
- Population
- Middle-aged and older Chinese adults, China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 7,115 participants
- Exposure
- Highest vs lowest tertile of triglyceride and glucose (TyG) index and modified TyG indices
- Outcome
- New-onset CVD
- Follow-up
- 7-year follow-up
Methodological detailsobservational, national representative cohort
- Observational
- National representative cohort
Main finding
As reported in the abstract
New-onset CVD, highest vs lowest tertile
Adjusted hazard ratio (95% CI)
TyG highest tertilevs TyG lowest tertile
1.215(1.088–1.356)
TyG-BMI highest tertilevs TyG-BMI lowest tertile
1.073(0.967–1.191)
TyG-WC highest tertilevs TyG-WC lowest tertile
1.078(0.970–1.198)
TyG-WHtR highest tertilevs TyG-WHtR lowest tertile
1.112(1.002–1.235)
- Developed CVD
- 2136 participants
- Coronary heart disease cases
- 1633
- Stroke cases
- 719
Observational data: associations, not effects.
Further findings
Predictive capacity (Harrell's C-index) for CVD onset
- C-indices of TyG index higher than other modified TyG indices
Coronary heart disease and stroke
- Similar results observed for coronary heart disease and stroke
Original publication
Comparison of triglyceride glucose index and modified triglyceride glucose indices in prediction of cardiovascular diseases in middle aged and older Chinese adults. Cardiovasc Diabetol. Published 29 May 2024. doi:10.
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