Lipids & metabolic liver disease
Meta‐analysis of clinically available pharmacotherapy of biopsy confirmed metabolic dysfunction associated steatohepatitis ( MASH )
Pooled result · MAS (steatohepatitis score) changeResult — go to the resultMD −1.27 UnitsAuthors' conclusion
Clinically available medications are beneficial in reversing MASH. Improvements in RSw/oF and RFw/oS were greater at earlier stages of fibrosis. Future analyses of drug effects should include assessments adjusted for baseline study characteristics of Fibrosis Grades and may evaluate whether preventive therapy will have long term benefits if started at earlier stages of MASLD.
Study context
- Population
- Randomised controlled trials (RCTs) with biopsy data in MASH; age 53.1 ± 5.8 SD years14 publications
- Participants
- 3,173 participants
- Comparison
- Clinically available medications vs placebo
- Outcome
- MAS (steatohepatitis score) change
Methodological detailsmeta-regression
- Meta-regression
Pooled result
As reported in the abstract
MD
−1.27 Units
P < 0.001
Further pooled results
| Outcome | MD (Units) | P value |
|---|---|---|
| Fibrosis Grades change± 0.03; improved with treatment | −0.352 | P < 0.001 |
MASLD Activity Scores (MAS) sub scores (steatosis, lobar inflammation, ballooning)
- Improved for dapagliflozin, semaglutide and pioglitazone (all p < 0.002)
RSw/oF and RFw/oS
- Relative rates of RSw/oF and RFw/oS found with resmetirom, semaglutide, tirzepatide and dapagliflozin (all p < 0.015)
Meta-regression: RSw/oF and RFw/oS vs baseline Fibrosis Grades
- RSw/oF inversely correlated with baseline Fibrosis Grades
- P = 0.025
- RFw/oS inversely correlated with baseline Fibrosis Grades
- P = 0.076
- Greater improvements of both at lower Fibrosis Grades
Original publication
Meta‐analysis of clinically available pharmacotherapy of biopsy confirmed metabolic dysfunction associated steatohepatitis ( MASH ). Diabetes Obes Metab. Published 9 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →