Lipids & metabolic liver disease
Serum glycolipids mediate the link between dietary antioxidants and mortality in metabolic syndrome
Authors' conclusion
Higher CDAI is associated with lower all-cause and cardiovascular mortality in MetS patients, potentially mediated through the regulation of glycolipid metabolism.
Study context
- Population
- Adults with metabolic syndrome (MetS) in NHANES (1999–2020)
- Participants
- 2,074 adults
- Exposure
- Composite dietary antioxidant index (CDAI) quartiles
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 76.24 months
Methodological detailsNHANES 1999-2020, weighted Cox proportional hazard regression, restricted cubic spline, stratified and mediation analyses
- NHANES 1999-2020
- Weighted Cox proportional hazard regression
- Restricted cubic spline
- Stratified and mediation analyses
Main finding
As reported in the abstract
Estimate (95% CI)P value
Q3vs Q1
HR (all-cause mortality) 0.63(0.45–0.90)
P = 0.025Q3vs Q1
HR (cardiovascular mortality) 0.54(0.32–0.93)
P = 0.023- Deaths
- 225
- Cardiovascular deaths
- 65
Observational data: associations, not effects.
Further findings
Stratified analyses
- Supported the findings, with no significant interactions
Mediation analysis
- Serum glucose and HDL-C mediated the relationship between CDAI and mortality
Original publication
Serum glycolipids mediate the link between dietary antioxidants and mortality in metabolic syndrome. Diabetes Res Clin Pract. Published 1 April 2026. doi:10.
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