Lipids & metabolic liver disease
Associations of liver fat content with cardiometabolic phenotypes and outcomes in a multi‐ethnic population: Results from the Dallas Heart Study
Authors' conclusion
Clinically relevant metabolic abnormalities were higher across quintiles of liver fat, with increases noted well within normal liver fat ranges, but cardiovascular events were not associated with liver fat content. Longitudinal changes in metabolic parameters, especially adiposity-related parameters, were correlated with change in liver fat content.
Study context
- Population
- Dallas Heart Study participants; mean age 44 years, 47% men, 48% African American343 at follow-up
- Participants
- 2,287 participants
- Exposure
- Liver fat quintiles/tertiles
- Outcome
- Cardiometabolic biomarkers across liver fat quintiles
- Follow-up
- Baseline
Methodological detailsmulti-ethnic, population-based, liver fat by magnetic resonance spectroscopy (MRS)
- Multi-ethnic
- Population-based
- Liver fat by MRS
Main finding
As reported in the abstract
- Body mass index (BMI), waist circumference, hypertension, diabetes, cholesterol, TG, hs-CRP, leptin, fasting glucose, HOMA-IR, coronary artery calcium, visceral, abdominal and lower body subcutaneous adipose tissue worsened across liver fat quintiles
- P < 0.0001
Observational data: associations, not effects.
Further findings
Cardiovascular events by tertile of baseline liver fat · >12 years
- Cardiovascular events comparable across liver fat tertiles
Correlation of changes with change in liver fat content · mean 7.3 years
- Change in BMI
- R = 0.40
- Change in waist circumference
- R = 0.35
- Change in C-reactive protein (CRP)
- R = 0.31
- Change in alanine aminotransferase
- R = 0.27
- Change in HOMA-IR
- R = 0.26
- Change in aspartate transaminase
- R = 0.15
- Change in TG
- R = 0.12
- P < 0.01 for all
Original publication
Associations of liver fat content with cardiometabolic phenotypes and outcomes in a multi‐ethnic population: Results from the Dallas Heart Study. Diabetes Obes Metab. Published 15 November 2022. doi:10.
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