Lipids & metabolic liver disease
The journey of MASLD: Tracking resolution, relapse, and predictive factors after sleeve gastrectomy and one-anastomosis gastric bypass, a propensity score-matched cohort study
Authors' conclusion
This study found no significant differences in MASLD resolution and relapse rates between SG and OAGB. Key factors influencing MASLD outcomes included the percentage of hepatic steatosis, 12-month EWL%, Pre-Op FM%, and age.
Study context
- Population
- Individuals with concurrent MASLD and obesity undergoing sleeve gastrectomy (SG) or one-anastomosis gastric bypass (OAGB), 2013–2023; 81.5% femalepropensity score-matched
- Participants
- 1,618 individuals
- Exposure
- SG vs OAGB
- Outcome
- Rates of MASLD resolution and relapse
- Follow-up
- Maximum 4 years; median 2.2 years (IQR 1.0-3.3)
Methodological detailsobservational, propensity score-matched
- Observational
- Propensity score-matched
Main finding
As reported in the abstract
median follow-up 2.2 years (IQR: 1.0-3.3)
Overall MASLD resolution rate
71.1 per 1000 person-month
Overall MASLD relapse rate
8.7 per 1000 person-month
Observational data: associations, not effects.
Further findings
Predictors of MASLD resolution
- Lower % hepatic steatosis, higher 12-month EWL% and younger age were significant resolution predictors
Predictors of MASLD relapse
- Increased % liver steatosis, higher pre-operative (Pre-Op) FM% and older age were significant relapse predictors
Original publication
The journey of MASLD: Tracking resolution, relapse, and predictive factors after sleeve gastrectomy and one-anastomosis gastric bypass, a propensity score-matched cohort study. Diabetes Res Clin Pract. Published 19 December 2024. doi:10.
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