Lipids & metabolic liver disease
Oxidized high‐density lipoprotein and low‐density lipoprotein in adolescents with obesity and metabolic dysfunction‐associated steatotic liver disease
Authors' conclusion
The elevated oxHDL and oxHDL/HDL-C in adolescents with MASLD compared to peers with Ob or NW suggests that there is some oxidative stress in MASLD independent of obesity and potential for increased CVD risk in the future.
Study context
- Population
- Adolescents (11–20 years)
- Participants
- 47 / 28 / 29
- Exposure
- Adolescents with obesity and MASLD vs peers with obesity without MASLD (obesity (Ob)) or normal weight (NW)
- MASLDn = 47
- Obn = 28reference
- NWn = 29reference
- Outcome
- Fasting oxidized high-density lipoprotein (oxHDL) and oxLDL
Main finding
As reported in the abstract
oxHDL
Relative difference
27%
P < 0.05
MASLD vs Ob
Relative difference
7%
P > 0.05
MASLD vs NW
Observational data: associations, not effects.
Further findings
oxLDL
| Outcome | Relative difference | P value |
|---|---|---|
| HDL-CMASLD vs Ob · lower with MASLD | 19% | |
| HDL-CMASLD vs NW · lower with MASLD | 32% | |
| oxHDL/HDL-C ratioMASLD vs Ob | 55% | P < 0.004 |
| oxHDL/HDL-C ratioMASLD vs NW | 66% | P < 0.001 |
Oxidized low-density lipoprotein (oxLDL)
- oxLDL, LDL-C and oxLDL/LDL-C ratio did not differ among groups
Original publication
Oxidized high‐density lipoprotein and low‐density lipoprotein in adolescents with obesity and metabolic dysfunction‐associated steatotic liver disease. Pediatr Obes. Published 16 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →