Longitudinal Analysis of Liver Chemistry Trajectories and Risk of Type 2 Diabetes in Children With Metabolic Dysfunction–Associated Steatotic Liver Disease: A Multicenter Cohort Study
Authors' conclusion
A 30-unit increase in GGT over time was associated with a substantially higher risk of developing type 2 diabetes in children with MASLD. Together with AST, GGT may provide clinicians with concrete, routinely available parameters to monitor for early risk stratification. Further validation in independent cohorts is needed to confirm these findings and inform clinical application.
Study context
- Population
- Children with biopsy-confirmed MASLD without T2D at baseline
- Participants
- 1,035 children
- Exposure
- Longitudinal increases in liver chemistries and T2D risk
- Outcome
- Incident T2D (fasting glucose, HbA1c, clinical diagnosis)
- Follow-up
- Mean 3.9 years
Methodological detailsextended Cox models with inverse probability weighting, Liver chemistries measured annually
- Extended Cox models with inverse probability weighting
- Liver chemistries measured annually
Main finding
As reported in the abstract
Cumulative incidence of T2D
12.3%
Increases in GGT and T2D risk (independent model), HR
1.55 (1.34-1.80) (95% CI)
Increases in AST and T2D risk (independent model), HR
1.31 (1.20-1.43) (95% CI)
Increases in ALT and T2D risk (independent model), HR
1.13 (1.07-1.20) (95% CI)
Observational data: associations, not effects.
Original publication
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