Lipids & metabolic liver disease
Similar weight loss with semaglutide regardless of diabetes and cardiometabolic risk parameters in individuals with metabolic dysfunction‐associated steatotic liver disease: Post hoc analysis of three randomised controlled trials
Authors' conclusion
People with MASLD/MASH had similar semaglutide-mediated weight loss regardless of type 2 diabetes status and other cardiometabolic risk parameters.
Study context
- Population
- Adults with MASLD or biopsy-confirmed MASH, with T2D, pre-T2D or no diabetes3 RCTs pooled · with T2D 209 · pre-T2D 51 · or no diabetes 40
- Participants
- 163 vs 137
- Comparison
- Semaglutide vs placebo
- Semaglutiden = 163
- Placebon = 137reference
- Primary endpoint
- Weight change by T2D status
- Follow-up
- 1 year
Methodological detailspooled analysis, placebo-controlled, 48-72-week trials, subgroup analysis by type 2 diabetes status
- Pooled analysis
- Placebo-controlled
- 48-72-week trials
- Subgroup analysis by type 2 diabetes status
Primary result
As reported in the abstract
Estimated treatment difference in weight change by T2D status
Estimated treatment difference (T2D)
−10.2 kg
−10.8%
Estimated treatment difference (pre-T2D)
−9.8 kg
−10.2%
Estimated treatment difference (no diabetes)
−11.6 kg
−13.1%
- Differences between subgroups not statistically significant
- P > 0.50 for all
Further findings
| Outcome | Semaglutide | Placebo |
|---|---|---|
| Overall mean weight change · 1 yearkg | −11.1 | −0.7 |
| Percent change | −11.7% | −0.6% |
Correlation of baseline cardiometabolic parameters with weight change
- Baseline FPG, HbA1c, insulin, insulin resistance and lipids did not correlate with weight change
Original publication
Similar weight loss with semaglutide regardless of diabetes and cardiometabolic risk parameters in individuals with metabolic dysfunction‐associated steatotic liver disease: Post hoc analysis of three randomised controlled trials. Diabetes Obes Metab. Published 28 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →