Lipids & metabolic liver disease
Prevalence and determinants of dyslipidemia in 2338 Dutch childhood cancer survivors: a DCCS-LATER 2 study
Authors' conclusion
CCS is at increased risk of dyslipidemia, with various modifiable and non-modifiable determinants identified, underscoring the importance of survivor-specific risk assessment tools to control cardiovascular morbidity and mortality in this high-risk population.
Study context
- Population
- Adult childhood cancer survivors (CCS) in a nationwide Dutch cohort (median age 34.7 year, median follow-up 27.1 year), compared with adults with no cancer history (Lifelines)
- Participants
- 2,338 vs 132,226
- Exposure
- Adult CCS vs adults with no cancer history
- CCSn = 2,338
- Lifelinesn = 132,226reference
- Outcome
- Prevalence of dyslipidemia, defined by multiple classifications and lipid abnormalities
Methodological detailsnationwide cohort, logistic regression adjusted for age, sex and BMI
- Nationwide cohort
- Logistic regression adjusted for age, sex and BMI
Main finding
As reported in the abstract
Dyslipidemia (NCEP-ATP-III, WHO, EGIR, CTCAEv.4.03)
- CCS had significantly increased odds of dyslipidemia vs reference cohort according to all classifications
- Adjusted for age, sex, and BMI
Observational data: associations, not effects.
Further findings
Lipid abnormalities in survivors without lipid-lowering agents (n = 2007)
- TG > 1.7 mmol/L
- 20.6%
- HDL-C < 1.0/1.3 mmol/L (male/female)
- 30.3%
- Total cholesterol > 5.2 mmol/L
- 29.9%
- LDL-C > 4.1 mmol/L
- 7.3%
- Apolipoprotein-B > 130 mg/dL
- 7.7%
Lipid abnormalities, survivors vs references without lipid-lowering agents (n = 126 631)
- High TG, survivors vs references: aOR
- 1.89 (1.68-2.13) (95% CI)
- Low HDL-C, survivors vs references: aOR
- 2.73 (2.46-3.03) (95% CI)
- High apolipoprotein-B, survivors vs references: aOR
- 1.84 (1.53-2.20) (95% CI)
Determinants of dyslipidemia in CCS
- Sex, age, BMI, physical activity, abdominal/pelvic, cranial and total body irradiation, alkylating agents, smoking, GHD and DM were associated with (≥1 definition of) dyslipidemia in CCS
- Multivariable logistic regression
Original publication
Prevalence and determinants of dyslipidemia in 2338 Dutch childhood cancer survivors: a DCCS-LATER 2 study. Eur J Endocrinol. Published 20 November 2024. doi:10.
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