Lipids & metabolic liver disease
Associations of Cumulative Adulthood, Childhood and Lifelong Insulin With Adulthood Retinal Microvasculature
Authors' conclusion
Cumulative childhood, adulthood, and lifelong insulin are associated with decreased retinal arteriolar diameter in adulthood in a population of participants without diabetes, independently of conventional cardiovascular risk factors.
Study context
- Population
- Participants without diabetes from the Cardiovascular Risk in Young Finns Study, fundus photos in 2011 at age 34 to 49 years
- Participants
- 1,166 participants
- Exposure
- Higher vs lower cumulative insulin exposure
- Outcome
- Retinal microvasculature (retinal arteriolar diameter) in adulthood
- Follow-up
- 2011
Methodological detailslongitudinal, 31-year follow-up from childhood to adulthood, Cumulative exposure as AUC for adulthood (2001–2011) and childhood (ages 6-18 years) insulin; lifelong AUC as their sum
- Longitudinal
- 31-year follow-up from childhood to adulthood
- Cumulative exposure as AUC for adulthood (2001–2011) and childhood (ages 6-18 years) insulin; lifelong AUC as their sum
Main finding
As reported in the abstract
Retinal arteriolar diameter
- Higher adulthood, childhood and lifelong cumulative insulin exposure associated with decreased retinal arteriolar diameter, adjusted for age and sex and further for cumulative conventional CV risk factors
Observational data: associations, not effects.
Original publication
Associations of Cumulative Adulthood, Childhood and Lifelong Insulin With Adulthood Retinal Microvasculature. J Clin Endocrinol Metab. Published 11 December 2024. doi:10.
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