Life Course Cumulative BMI Burden From Childhood to Adulthood and Risk of Metabolic Multimorbidity: A 36-Year Prospective Cohort Study
Study context
- Population
- Participants of the Hanzhong Adolescent Hypertension Study (1987–2023) with at least two BMI measurements in both childhood (6–18 years) and adulthood (19–52 years)
- Participants
- 2,446 participants
- Exposure
- Higher vs lower cumulative BMI burden (total and incremental AUC) in childhood, adulthood and over the life course
- Outcome
- Adult metabolic multimorbidity: two or more metabolic diseases (hypertension, DM, dyslipidemia, elevated liver enzymes/bilirubin, kidney damage)
Methodological detailsHanzhong Adolescent Hypertension Study (1987-2023)
- Hanzhong Adolescent Hypertension Study (1987-2023)
Main finding
As reported in the abstract
Metabolic multimorbidity (two or more diseases)
- Total BMI AUC (childhood, adulthood, life course): OR range, all P < 0.05
- 1.51 to 2.59
- Incremental BMI AUC (childhood, adulthood, life course): OR range, all P < 0.05
- 1.94 to 4.33
- Childhood incremental AUC: OR
- 4.33 [2.93, 6.40] (95% CI)
- Childhood total AUC: OR
- 1.51 [1.17, 1.95] (95% CI)
- Total AUC showed a stronger association in adulthood than in childhood: OR
- 2.51 [2.08, 3.04] vs. 1.94 [1.62, 2.31] (95% CI)
Observational data: associations, not effects.
Further findings
Metabolic multimorbidity by sex (adulthood and life course BMI AUC)
- Associations significantly stronger in males than in females
- P for interaction < 0.05
Original publication
Life Course Cumulative BMI Burden From Childhood to Adulthood and Risk of Metabolic Multimorbidity: A 36-Year Prospective Cohort Study. Diabetes Care. Published 22 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →