BMI change during childhood, DNA methylation change at TXNIP, and glucose change during midlife
Authors' conclusion
These results indicate that changes in blood DNAm at TXNIP are significantly associated with changes in FPG in midlife, and this association was modified by BMI trends during childhood and adolescence.
Study context
- Population
- Bogalusa Heart Study participants with blood DNA methylation (DNAm) measured at two time points in midlife; 353 had ≥4 BMI measurements in childhood and adolescence353 with childhood BMI
- Participants
- 594 participants
- Exposure
- Change in DNAm at TXNIP vs change in fasting plasma glucose (FPG), by tertile of childhood BMI incremental AUC
- Outcome
- Association of change in DNAm at TXNIP with change in FPG
- Follow-up
- Midlife
Main finding
As reported in the abstract
Increase in DNAm at TXNIP and change in FPG
- Increase in DNAm at TXNIP significantly associated with decrease in FPG independent of covariates
- p < 0.001
- Association modified by childhood/adolescent increasing BMI trend
- p-interaction = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | Highest tertile | Middle tertile |
|---|---|---|
| FPG decrease per 1% increase in DNAm at TXNIP, by tertile of BMI incremental AUC | 2.90 (unspecified 0.77) mg/dL decrease | 0.96 (unspecified 0.38) mg/dL decrease |
FPG decrease per 1% increase in DNAm at TXNIP, by tertile of BMI incremental AUC
- Lowest tertile: no association observed
Original publication
BMI change during childhood, DNA methylation change at TXNIP, and glucose change during midlife. Obesity (Silver Spring). Published 6 July 2023. doi:10.
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