Epigenetic Age in Peripheral Blood Among Children, Adolescent, and Adult Survivors of Childhood Cancer
Authors' conclusion
The findings of this study suggest that EAA measured in children and adolescent survivors of childhood cancer is associated with early-onset obesity, severity/burden of all CHCs, and late mortality. Evaluating EAA may help identify survivors of childhood cancer at increased risk for early-onset obesity, morbidity in general, and mortality.
Study context
- Population
- Survivors of childhood cancer of European ancestry with DNA methylation data, St Jude Lifetime Cohort; median age 30.3 (IQR 9.3–41.5) years; 53% males690 aged <20 years
- Participants
- 2,846 survivors
- Exposure
- Epigenetic age acceleration and outcomes; Epigenetic age (EA) change across 5 age groups
- Outcome
- Early-onset obesity, high severity/burden of CHCs and late mortality
- Follow-up
- Until April 2020
Methodological detailscross-sectional analysis, Conducted April 17, 2022, to March 23, 2023
- Cross-sectional analysis
- Conducted April 17, 2022, to March 23, 2023
Main finding
As reported in the abstract
Association of each 1-SD increase in Levine EEA with outcomes
Early-onset obesity, OR
1.46 (1.19-1.78) (95% CI)
High severity/burden of chronic health conditions (CHCs), OR
1.13 (1.03-1.24) (95% CI)
Late mortality, HR
1.75 (1.35-2.26) (95% CI)
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Cross-sectional annual change in EA_LevineHigher in children and adolescents | Children 1.63 years · Adolescents 1.14 years |
| Adjusted least-squares mean Levine EEALower in children and older adults | Children adjusted least-squares mean −0.22 years · Older adults adjusted least-squares mean −1.70 years |
Original publication
Epigenetic Age in Peripheral Blood Among Children, Adolescent, and Adult Survivors of Childhood Cancer. JAMA Netw Open. Published 3 April 2023. doi:10.
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