Immune Cell‐Stratified Regulatory Contexts Associated With Body Mass Index (BMI) ‐Related Multi‐System Disease Risk: A Cell‐Stratified Mendelian Randomization Study Using Single‐Cell eQTL Data
Authors' conclusion
These findings prioritize CD4+ T cell regulatory contexts as potential immunogenetic links between BMI and multi-system disease risk, while requiring further validation in diverse populations and mechanistic models.
Study context
- Population
- European-ancestry BMI GWAS data; GWAS datasets for 33 disease outcomes across five disease systems; single-cell cis-eQTL data from 28 peripheral blood immune cell types and dynamic CD4+ T cell eQTL data
- Outcome
- BMI-related genetic associations with disease outcomes
Methodological detailscell-stratified, single-cell eQTL, SuSiE-based colocalization
- Cell-stratified
- Single-cell eQTL
- SuSiE-based colocalization
Main finding
As reported in the abstract
- Colocalized variants identified across 28 immune cell types
- 1326
- Genes regulated by colocalized variants
- 1426
- Disease outcomes with Bonferroni-significant associations with genetically predicted BMI in primary MR analyses
- 26
- Bonferroni-significant associations in cell-stratified analyses
- 87
- Disease outcomes with cell-stratified Bonferroni-significant associations
- 17
Original publication
Immune Cell‐Stratified Regulatory Contexts Associated With BMI ‐Related Multi‐System Disease Risk: A Cell‐Stratified Mendelian Randomization Study Using Single‐Cell eQTL Data. Diabetes Obes Metab. Published 13 July 2026. doi:10.
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