Circulating mediators linking cardiometabolic diseases to heart failure with preserved ejection fraction (HFpEF): a mediation Mendelian randomization analysis
Authors' conclusion
These findings suggest that metabolic HFpEF has distinct etiological features compared with HFrEF and is driven by complex, condition-specific mediators. IL1R1 mediates HFpEF in multiple metabolic risk states, suggesting a potential therapeutic target. Further translational studies are warranted to evaluate anti-inflammatory strategies targeting IL1R1 in HFpEF.
Study context
- Population
- Large European-ancestry GWAS datasets
- Comparison
- Cardiometabolic diseases as exposures for HFpEF and HFrEF
- Outcome
- Causal effects of cardiometabolic diseases on HFpEF and mediators
Methodological detailstwo-sample, mediation Mendelian Randomization (MR), multivariable MR
- Two-sample
- Mediation MR
- Multivariable MR
Main finding
As reported in the abstract
Proteins mediating obesity to HFpEF
5
Proteins mediating T2D to HFpEF
5
Original publication
Circulating mediators linking cardiometabolic diseases to HFpEF: a mediation Mendelian randomization analysis. Cardiovasc Diabetol. Published 12 May 2025. doi:10.
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