Early‐life body mass index and the risk of six cardiovascular diseases: A Mendelian Randomization study
Authors' conclusion
Genetically inferred early-life BMI is significantly associated with six distinct CVDs. This indicates that elevated early-life BMI is a significant risk factor for multiple cardiovascular disorders.
Study context
- Population
- Summary-level GWAS datasets: early-life body mass index (BMI) (age 2–10) and heart failure (HF), atrial fibrillation (AF), coronary artery disease (CAD), peripheral artery disease (PAD), deep venous thrombosis (DVT) and myocardial infarction (MI) outcomesearly-life BMI GWAS n = 61,111
- Comparison
- Genetically predicted early-life BMI and risk of six cardiovascular diseases (CVDs)
- Outcome
- Causal relationship between early-life BMI and six types of CVDs (HF, AF, CAD, PAD, DVT, MI)
Methodological detailssummary-level GWAS data, multiple Mendelian Randomization (MR) methods, sensitivity analysis
- Summary-level GWAS data
- Multiple MR methods
- Sensitivity analysis
Main finding
As reported in the abstract
Six CVDs per elevated childhood BMI
- HF: OR (95% CI) p
- 1.319 (1.160 to 1.499), p = 2.33 × 10-5
- AF: R (95% CI) p
- 1.183 (1.088 to 1.287), p = 8.22 × 10-5
- CAD: OR (95% CI) p
- 1.148 (1.028 to 1.283), p = 1.47 × 10-2
- PAD: OR (95% CI) p
- 1.405 (1.233 to 1.600), p = 3.10 × 10-7
- MI: OR (95% CI) p
- 1.120 (1.017 to 1.234), p = 2.18 × 10-2
- DVT: OR (95% CI) p
- 1.005 (1.001 to 1.008), p = 2.13 × 10-3
Original publication
Early‐life body mass index and the risk of six cardiovascular diseases: A Mendelian Randomization study. Pediatr Obes. Published 12 August 2024. doi:10.
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