Gut-muscle communication links FGF19 levels to the loss of lean muscle mass following rapid weight loss
Authors' conclusion
These data identify gut-muscle communication and FGF19 as a potentially important mediator of the preservation of lean muscle mass during rapid weight loss.
Study context
- Population
- Subjects with obesity undergoing rapid weight loss
- Participants
- 176 subjects
- Exposure
- FGF19 levels before vs after VLED-induced weight loss
- VLEDn = 176
- Outcome
- Whether FGF19 levels are predictive of lean muscle mass following rapid weight loss
- Follow-up
- After 3-4 months VLED
Methodological detailssingle-group weight loss intervention, multiple linear regression
- Single-group weight loss intervention
- Multiple linear regression
Main finding
As reported in the abstract
FGF19 levels as predictor of percent lean muscle mass after VLED
- Baseline (obesity) FGF19 levels, but not post-VLED FGF19 levels, significantly predicted the percent of lean muscle mass after VLED-induced weight loss, controlling for age, sex and baseline percent lean mass
- Multiple linear regression
Observational data: associations, not effects.
Further findings
Postprandial FGF19 levels · baseline to after VLED
- Postprandial FGF19 levels increased significantly following VLED-weight loss
Original publication
Gut-muscle communication links FGF19 levels to the loss of lean muscle mass following rapid weight loss. Diabetes Metab. Published 10 August 2024. doi:10.
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