Associations between phenotypes of childhood and adolescent obesity and incident hypertension in young adulthood
Authors' conclusion
Risk for incident hypertension in young adulthood varied by childhood obesity phenotypes, as well as by biological sex. If replicated, these results may suggest that increased surveillance of specific childhood obesity phenotypes might help in targeting those at highest risk for hypertension.
Study context
- Population
- Participants in the Growing Up Today Study, US prospective cohort established in 1996
- Participants
- 11,404 participants
- Exposure
- Childhood obesity phenotypes vs no childhood overweight/obesity
- Outcome
- Incident hypertension
- Follow-up
- Ages 20-35 years
Methodological detailslatent class analysis-derived phenotypes, logistic regression with generalized estimating equations, stratified by sex
- Latent class analysis-derived phenotypes
- Logistic regression with generalized estimating equations
- Stratified by sex
Main finding
As reported in the abstract
Incident hypertension in young adulthood
Each group vs no overweight/obesityOdds ratio (95% CI)
Early pubertyfemales
2.52(1.75–3.62)
MOfemales
2.98(1.93–4.59)
WCfemales
2.33(1.65–3.28)
Mixedfemales
1.66(1.25–2.20)
MOmales
2.65(1.82–3.87)
WCmales
3.52(2.38–5.20)
Mixedmales
1.51(1.23–1.86)
- Among males, mothers with obesity (MO) and weight concerns (WC) phenotypes had a greater risk of hypertension than the mixed subtype
- P = 0.004
Observational data: associations, not effects.
Original publication
Associations between phenotypes of childhood and adolescent obesity and incident hypertension in young adulthood. Int J Obes (Lond). Published 16 December 2024. doi:10.
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