Impact of prenatal exposure to delta 9‐tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories
Authors' conclusion
Our study suggests that prenatal exposure to Δ9-THC may alter early-life growth. Breastfeeding may stabilize rapid postnatal growth, but the impact of lactational exposure requires further investigation.
Study context
- Population
- Mother-child pairs followed through 3 years; urinary Δ9-THC and cannabidiol (CBD) measured mid-gestation
- Participants
- 128 mother-child pairs
- Exposure
- Prenatal Δ9-THC exposure vs no exposure
- Outcome
- Neonatal body composition and BMI z-score trajectory with prenatal Δ9-THC exposure alone
Methodological detailsexploratory
- Exploratory
Main finding
As reported in the abstract
Fat mass with prenatal Δ9-THC alone
−95 g
95% CI −174, −14
Neonatal adiposity with prenatal Δ9-THC alone
−2.1%
95% CI −4.2, −0.4
Postnatal growth: increase in body mass index (BMI) z-score per square root year
0.42
95% CI 0.12, 0.72
Observational data: associations, not effects.
Further findings
Modification by breastfeeding of the Δ9-THC–postnatal growth association · 3 years
- Interaction with breastfeeding
- P = 0.04
- Shorter breastfeeding: higher BMI z-score at 3 years
- 1.1 (95% CI: 0.21, 2.05)
- Growth similar with breastfeeding for 5 months
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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