Associations between maternal metabolic parameters during pregnancy and fetal and child growth trajectories from 20 weeks' gestation to 5 years of age: Secondary analysis from the ROLO longitudinal birth cohort study
Authors' conclusion
In a cohort of women with obesity with infants at risk of macrosomia, maternal metabolic markers were not strongly associated with trajectories of weight or abdominal circumference from 20 weeks gestation to 5 years of age.
Study context
- Population
- Mother-child pairs from the ROLO study (RCT of low glycaemic index diet on recurrence of macrosomia); women with obesity with infants at risk of macrosomia
- Primary endpoint
- Associations of maternal fasting glucose, insulin, HOMA-IR and leptin (14-16 and 28 weeks) with weight and abdominal circumference trajectories
- Follow-up
- 20 weeks gestation to 5 years of age
Methodological detailslinear spline multilevel models
- Linear spline multilevel models
Primary result
As reported in the abstract
Weight and abdominal circumference trajectories · 20 weeks gestation to 5 years
- No strong evidence of associations between any maternal metabolic parameters and fetal to childhood weight and abdominal circumference trajectories
Original publication
Associations between maternal metabolic parameters during pregnancy and fetal and child growth trajectories from 20 weeks' gestation to 5 years of age: Secondary analysis from the ROLO longitudinal birth cohort study. Pediatr Obes. Published 14 September 2022. doi:10.
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