Maternal pre‐pregnancy body mass index and offspring with overweight/obesity at preschool age: The possible role of epigenome‐wideDNAmethylation changes in cord blood
Authors' conclusion
DNA methylation in FOXN3 and AHRR is associated with overweight/obesity in preschool-aged children, and the methylation in FOXN3 and ZNF264 might be associated with children's BMI-z score. FOXN3 methylation may be associated with maternal pre-pregnancy BMI, suggesting its potential role in the children's BMI-z score or overweight/obesity. Our results provide novel insights into the mechanisms of children's obesity.
Study context
- Population
- Mother-child pairs of the Zhuhai birth cohort with newborn cord blood, maternal pre-pregnancy body mass index (BMI) and children's BMI at 3 yearsstage 1 genome-wide DNA methylation (GWDm) pairs
- Participants
- 30 pairs
- Exposure
- Preschoolers with overweight/obesity vs normal-weight controls; association with maternal pre-pregnancy BMI and children's BMI-z score
- Overweight/obesityn = 10
- Controlsn = 10reference
- Outcome
- Cord blood DNA methylation (CpG sites)
- Follow-up
- BMI at 3 years
Methodological detailstwo-stage design, genome-wide DNA methylation analysis, targeted validation with matched controls
- Two-stage design
- Genome-wide DNA methylation analysis
- Targeted validation with matched controls
Main finding
As reported in the abstract
- Stage 2: significant difference of CpG sites in AHRR (chr5:355067-355068) and FOXN3 (chr14: 89630264-89630272 and chr14: 89630387-89630388) between overweight/obesity and controls
- p < 0.05
Observational data: associations, not effects.
Original publication
Maternal pre‐pregnancy body mass index and offspring with overweight/obesity at preschool age: The possible role of epigenome‐wideDNAmethylation changes in cord blood. Pediatr Obes. Published 14 September 2022. doi:10.
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