Pre-pregnancy body mass index and biomarkers of inflammation at birth
Authors' conclusion
High pre-pregnancy BMI was associated with elevated CRP levels in cord blood, reflecting higher inflammatory marker levels in the perinatal environment.
Study context
- Population
- Mother–infant pairs in two birth cohorts (EDEN, ELFE); inflammatory biomarkers (IL-1β, IL-6, IL-10, TNF-α, C-reactive protein (CRP)) in maternal serum at birth (ELFE) and cord blood (both cohorts)two birth cohorts
- Exposure
- Pre-pregnancy body mass index (BMI) categories
- Outcome
- Cord blood CRP
- Follow-up
- Birth
Methodological detailstwo birth cohorts (EDEN, ELFE), linear regression adjusted for confounders
- Two birth cohorts (EDEN, ELFE)
- Linear regression adjusted for confounders
Main finding
As reported in the abstract
Adjusted β
0.52
95% CI 0.32–0.72
Pre-pregnancy obesity · ELFE cohort
Adjusted β
0.32
95% CI 0.12–0.54
Maternal overweight · EDEN cohort
Observational data: associations, not effects.
Further findings
| Outcome | β (CI) |
|---|---|
| Cord blood IL-10 (ELFE) · birthUnderweight vs Normal · ELFE | 0.20 (0.04–0.35) |
Maternal serum biomarkers (ELFE) · birth
- Pre-pregnancy BMI not associated with any maternal serum biomarker in overall analyses
Original publication
Pre-pregnancy body mass index and biomarkers of inflammation at birth. Int J Obes (Lond). Published 12 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →