Association of Maternal TSH, Free Thyroxine (FT4) With Children's Body Mass Index (BMI) Trajectories, and Obesity: A Birth Cohort Study
Authors' conclusion
Low maternal FT4 trajectory during pregnancy may predict a high BMI trajectory in children and relate to overweight and high body fat ratio in 6-year-old children. High maternal FT4 concentrations throughout pregnancy may be associated with the decreasing risk of obesity and low body fat ratio in 6-year-old children.
Study context
- Population
- Mother–child pairs, Ma'anshan Birth Cohort, China; maternal thyroid function assayed in 3 trimesters; children's height and weight measured 15 times before age 6 years
- Exposure
- Low maternal FT4 trajectory vs reference trajectory; maternal FT4 concentrations by trimester
- Outcome
- Children's BMI trajectories and obesity
- Follow-up
- Before age 6 years
Main finding
As reported in the abstract
Low maternal FT4 trajectoryOdds ratio (95% CI)
High children's BMI trajectory
1.580(1.169–2.135)
Overweight
1.505(1.064–2.129)
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) |
|---|---|
| Body fat ratio at age 6 yearsPositive association | 0.983 (0.138–1.829) |
Body fat ratio at age 6 years
- Negative correlations between maternal FT4 concentration in the first, second and third trimesters and body fat ratio
Original publication
Association of Maternal TSH, FT4 With Children's BMI Trajectories, and Obesity: A Birth Cohort Study. J Clin Endocrinol Metab. Published 1 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →