The various associations between whole /regional fat mass and trajectory of cardiometabolic diseases: a nonlinear multistate model
Authors' conclusion
Body fat composition and distribution revealed various associations with CMD trajectory, highlighting their clinical importance. Upper body FM among those participants with FCMD or cardiometabolic multimorbidity demonstrated positive J-shaped associations toward death, providing no evidence of the "obesity paradox."
Study context
- Population
- UK Biobank participants; mean age 56.1 (SD 8.10) years, 43.9% men
- Participants
- 423,966 participants
- Exposure
- Whole body and regional fat mass as exposures
- Outcome
- Transitions in the cardiometabolic disease (CMD) trajectory
- Follow-up
- Median 13.5 years
Methodological detailsUK Biobank, nonlinear multistate model
- UK Biobank
- Nonlinear multistate model
Main finding
As reported in the abstract
Transitions in CMD trajectory
Leg fat mass (FM), transition from first CMD (FCMD) to death: HR per 1 kg
0.950
95% CI 0.931–0.968
Observational data: associations, not effects.
Original publication
The various associations between whole /regional fat mass and trajectory of cardiometabolic diseases: a nonlinear multistate model. Obesity (Silver Spring). Published 16 December 2024. doi:10.
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