Genetic variation in the RETN promoter, accompanied by latent sarcopenic obesity, led to insulin resistance in a Japanese cohort: the Toon Genome Study
Authors' conclusion
The G-A haplotype, accompanied by latent low skeletal muscle mass and visceral obesity, led to the deterioration of insulin resistance over a 5 year period in this cohort, possibly through the altered expression of mitophagy-related genes.
Study context
- Population
- Japanese adults attending annual medical checkups (average age 62 years), Toon Genome Study
- Participants
- 803 adults
- Exposure
- RETN promoter G-A haplotype vs C-G haplotype
- G-An = 25
- C-Gn = 33reference
- Outcome
- Insulin resistance over 5 years
- Follow-up
- 5 years
Methodological details5-yearly evaluations, hierarchical clustering, propensity-score matched RNA-seq substudy
- 5-yearly evaluations
- Hierarchical clustering
- Propensity-score matched RNA-seq substudy
Main finding
As reported in the abstract
- G-A haplotype with latent skeletal muscle loss and visceral obesity (latent sarcopenic obesity): pronounced deterioration in insulin resistance (multivariate analysis)
- Cluster 2 (low skeletal muscle mass, visceral obesity, insulin resistance) with the G-A haplotype: deterioration in insulin resistance
- Altered expression of mitophagy-related genes in whole blood cells of G-A homozygotes (RNA-seq, RT-PCR)
Observational data: associations, not effects.
Original publication
Genetic variation in the RETN promoter, accompanied by latent sarcopenic obesity, led to insulin resistance in a Japanese cohort: the Toon Genome Study. Diabetologia. Published 13 December 2024. doi:10.
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